Phenylpropanoids and polyketides
TARGETMOL CHEMICALS INC Neohesperidin 500MG
Also available in 1 g, 5 g, 1 mL, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Neohesperidin (NSC-31048) with antioxidant and neuroprotective properties. Unlike other citrus flavanones, it does not inhibit oral carcinogenesis in a rat model. Purity 98.34%
Cell Signaling Technology Phospho-Akt (Thr450) (D5G4) Rabbit mAb 20 ul
Phospho-Akt (Thr450) (D5G4) Rabbit mAb 20 ul
Medchemexpress LLC Doxorubicin (hydrochloride) | 25316-40-9 | MFCD00077757 | C27H30ClNO11 | 5 G
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. It is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. It also induces apoptosis and autophagy.
- Cytotoxic anthracycline antibiotic
- Anti-cancer chemotherapy agent
- Potent human DNA topoisomerase I and topoisomerase II inhibitor (IC50s of 0.8 μM and 2.67 μM)
- Reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase
- Induces apoptosis and autophagy
Medchemexpress LLC Chalcone | 94-41-7 | 100.0% | 50 MG
Chalcone is the parent α,β-unsaturated ketone scaffold used widely as a small-molecule research chemical and synthetic building block. Provided as a high-purity solid, it is used in medicinal chemistry, biochemical assays, and the synthesis of chalcone derivatives. Typical identifiers: CAS 94-41-7; formula C15H12O; molecular weight 208.25 g/mol.
- High purity suitable for research use.
- Useful building block for synthesis of bioactive derivatives.
- Compatible with DMSO; available as solution for screening.
- Supplied with certificate of analysis and safety data for quality and safety.
- Available in small-scale quantities for discovery research.
Medchemexpress LLC Troxerutin | 7085-55-4 | 98.0% | 742.68 | 10 G
Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins. It is capable of inhibiting the production of reactive oxygen species (ROS) and depressing ER stress-mediated NOD activation.
- Inhibits ROS production
- Depresses ER stress-mediated NOD activation
- Lowers body weight and improves metabolic parameters
- Restores glucose intolerance and insulin signaling
- Attenuates vascular damages
Apexbio Technology LLC 7,8-Dihydroxyflavone 38183-03-8 50mg
7 8-Dihydroxyflavone (CAS 38183-03-8) is a small-molecule compound that acts as a selective agonist of the tropomyosin receptor kinase B (TrkB) By mimicking the action of brain-derived neurotrophic factor (BDNF) it activates TrkB-mediated signaling pathways resulting in enhanced neuronal survival and modulation of synaptic plasticity 7 8-Dihydroxyflavone is widely utilized in experimental studies on neurodegenerative diseases and neurological disorders serving as a valuable tool for investigating neurotrophic signaling mechanisms and the development of potential therapeutics for central nervous system pathologies
Apexbio Technology LLC Icariin 489-32-7 100mg
Icariin (CAS 489-32-7) is a small-molecule inhibitor targeting phosphodiesterases notably PDE5 and PDE4 It is designed to modulate cyclic nucleotide signaling by inhibiting PDE activity thereby regulating processes such as smooth muscle relaxation and neuronal signaling Icariin exerts its biological activity primarily through the inhibition of PDE5 (IC 0 43 M) and PDE4 (IC 73 50 M) Based on these pharmacological properties icariin holds research potential in the investigation of erectile function nitric oxide synthase expression angiogenesis pathways and osteogenic differentiation in bone marrow stromal cells
Medchemexpress LLC Brepocitinib (P-tosylate) | 2140301-96-6 | 100.0% | 561.60 | 1 ML
Brepocitinib P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor. It inhibits JAK1 with an IC50 of 17 nM and TYK2 with an IC50 of 23 nM. It also inhibits JAK2 with an IC50 of 77 nM and JAK3 with an IC50 of 6.49 μM. This compound demonstrates in vitro efficacy in inhibiting various STAT pathways and in vivo efficacy by reducing paw volume in an arthritis model.
- Potent dual inhibitor of JAK1 and TYK2
- Specific inhibition of JAK2 and JAK3 at higher concentrations
- In vitro efficacy in inhibiting STAT pathways
- In vivo efficacy in an animal model of arthritis
- Solid, white to off-white color
- Intended for research purposes only
eMolecules AstaTech / 24-DICHLORO-DL-PHENYLALANINE / 0.25g / 718055058 / 60594 / 97.000 / 5472-68-4 / MFCD05227922 / 234.080 / C9H9Cl2NO2
AstaTech / 24-DICHLORO-DL-PHENYLALANINE / 0.25g / 718055058 / 60594 / 97.000 / 5472-68-4 / MFCD05227922 / 234.080 / C9H9Cl2NO2
Medchemexpress LLC Doxorubicin (hydrochloride) | 25316-40-9 | C27H30ClNO11 | 100 MG
Doxorubicin hydrochloride (Standard) is an analytical standard and cytotoxic anthracycline antibiotic, primarily used as an anti-cancer chemotherapy agent. It functions as a potent human DNA topoisomerase I and topoisomerase II inhibitor, reducing basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase, while also inducing apoptosis and autophagy.
- Intended for research and analytical applications
- Functions as a cytotoxic anthracycline antibiotic
- Acts as an anti-cancer chemotherapy agent
- Potent human DNA topoisomerase I and II inhibitor
- Induces apoptosis and autophagy
- Used in qualitative and quantitative research experiments
- Suitable for HPLC, GC, and MS applications